【摘 要】
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Dear Edltor,Receptor-interacting protein 3 (RIP3) is a serine/threonine protein kinase,which has extensive substrates including its cognate kinase RIP1 and mult
【机 构】
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Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Ma
论文部分内容阅读
Dear Edltor,Receptor-interacting protein 3 (RIP3) is a serine/threonine protein kinase,which has extensive substrates including its cognate kinase RIP1 and multiple metabolic enzymes involv-ing oxidative phosphorylation[1,2].RIP3 has been shown to be essential for development,immunity and some physiological or pathophysiological responses to exogenous and endoge-nous stimuli[3-5].In 2009,three groups independently reported that RIP3 acted as a molecular switch between apoptosis and necrosis (also called as necroptosis)[6-8].Specifically,RIP3could tu tumor necrosis factor (TNF)-induced cell death from apoptosis to necrosis[6].Most of small-molecule antican-cer drugs elicit their anticancer effects via apoptotic induc-tion[9].However,it is unclear whether RIP3 affects the cellular sensitivity to small-molecule anticancer drugs.
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