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目的：评价规范化使用抗菌药对预防Ⅰ类切口手术部位感染的影响及经济效果。方法：选取某院2011年5月~2013年4月6种常见Ⅰ类切口手术出院病例594例，分为规范化和非规范化抗菌药预防使用组，分别对两组手术部位感染率、住院天数、总住院费用及药品费用等进行比较分析。结果：非规范化组抗菌药使用率为100%，而规范化组为29%(P0.05)，治疗药品费用规范化组明显低于非规范化组(P<0.01)。结论：规范化使用抗菌药并未增加Ⅰ类切口手术部位感染率，且能降低药品费用，降低抗菌药的使用及耐药风险。“,”Objective:To evaluate the effect of standardized use of antibiotics in type I incision operation on preventing the infec-tion and expenses. Methods:Totally 594 medical records covering 6 kinds of common type I incision operations were selected from one hospital from May 2011 to April 2013. The medical records were divided into the standardized group and non-standardized group. Com-parison analysis was performed concerning the infection percentage, hospitalization period, hospitalization costs and medicine expenses between the two groups. Results:The usage ratio of antibacterial agents in the non-standardized and standardized group was 100% and 29% (P0. 05). Medicine expenses of the standardized group was significantly lower than that of non-standardized group (P<0. 01). Conclusion:The standardized use of antibacterial agents does not increase the rate of type I inci-sion operation site infection, and can significantly reduce the medicine expenses and lower the usage risk and resistance of antimicrobial agents.