以邻氨基苯硫酚为原料,先与羟基乙酸反应合成2-羟甲基苯并噻唑,然后通过氧化反应生成苯并噻唑-2-甲醛。对比了几种氧化剂的效果,发现二氧化锰氧化的效果最好。优化的反应条件为,2-羟甲基苯并噻唑与二氧化锰的摩尔比为1∶8,回流反应8h,产率可达90.2%。该方法适合苯并噻唑-2-甲醛及其衍生物的大规模生产。 O-aminothiophenol as raw material, first with glycolic acid synthesis of 2-hydroxymethyl benzothiazole, and then through the oxidation reaction of benzothiazole-2-carbaldehyde. Compare the effect of several oxidants and found that manganese dioxide oxidation is the best. The optimized reaction conditions were as follows: the molar ratio of 2-hydroxymethylbenzothiazole to manganese dioxide was 1: 8, and the reaction was carried out for 8 hours under reflux, yielding 90.2%. This method is suitable for large-scale production of benzothiazole-2-carbaldehyde and its derivatives.