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目的:观察东川芎乙醇提取物对小鼠学习记忆的改善作用。方法:腹腔注射氢溴酸东莨菪碱注射液(SCOP)制备小鼠记忆障碍模型,采用避暗实验、跳台实验、水迷宫实验和Y型电迷宫穿梭实验等方法观察不同剂量东川芎乙醇提取物对记忆障碍模型小鼠的作用效果。结果:与模型组比较,东川芎乙醇提取物中、高浓度组均能改善记忆障碍,作用强度类似于石杉碱甲。结论:东川芎乙醇提取物对SCOP诱导的小鼠记忆障碍具有良好的改善作用。
Objective: To observe the effect of Dongchongxiong ethanol extract on learning and memory in mice. Methods: The model of memory impairment was prepared by intraperitoneal injection of scopolamine hydrobromide (SCOP). The effects of ethanol extract of Dongchuanxiong at different doses on the memory were observed by the methods of avoiding darkness, jumping test, water maze test and Y-type electric maze test. Obstructive model mice effect. Results: Compared with the model group, the ethanol extract of Tung Chuanxiong, high concentration group can improve memory impairment, the intensity of action similar to huperzine A. Conclusion: Ethanol extract of Dongchuanxiong can improve the memory impairment of mice induced by SCOP.