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目的 探讨各种行为问题儿童外周血5-羟色胺（5-HT）浓度的变化及其意义。方法 应用《Achen-bach儿童行为量表》筛查并根据其因子分类,对30例行为问题儿童进行外周血5-HT含量测定,并与正常儿童30例对照比较。结果 行为问题儿童与正常儿童外周血5-HT浓度比较无明显变化（P>0.05）;多动行为问题儿童与正常儿童外周血5-HT浓度比较明显降低,差异显著（P<0.05）;内向型因子组与外向型因子组比较明显升高,差异显著（P<0.05）;行为问题儿童外周血5-HT浓度随着年龄的增长与正常儿童差异增大。结论外周血5-HT浓度与行为问题有关,可能是儿童行为问题发生的物质基础之一。
Objective To investigate the changes of 5-hydroxytryptamine (5-HT) concentration in children with various behavioral problems and its significance. Methods The Achen-bach Children’s Behavior Scale was used to screen and determine the 5-HT levels of peripheral blood in 30 children with behavioral problems according to the factor classification. The results were compared with those of 30 normal children. Results There was no significant difference in the concentration of 5-HT between children with behavioral problems and normal children (P> 0.05). The concentrations of 5-HT in children with hyperactivity disorder and normal children were significantly lower than those in normal children (P <0.05) Type factor group and the outward-oriented factor group were significantly higher (P <0.05); 5-HT concentration in children with behavioral problems increased with age and normal children increased. Conclusions The concentration of 5-HT in peripheral blood is related to behavioral problems, which may be one of the material bases for children’s behavioral problems.