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呋喃硝胺(Ranitidiue)是继甲氰咪胍之后,在近年合成的新一代组胺(H_2)受体阻断剂,该药能显著抑制胃酸分泌,对十二指肠球部溃疡有显著疗效。 我校第一医院唐承薇等首次用国产呋喃硝胺(重庆医药工业研究所合成)治疗169例十二指肠球部溃疡,常规剂量为每日300mg(150mg每日二次),疗程6周,经内窥镜观察,疗效显著优于甲氰咪胍每日1000mg(200mg每日三次、400mg每晚一次),愈合率分别为89％及69％(P<0.01)。临床应用还表明呋喃硝胺的副反应较甲氰咪胍少,短期应用对白细胞、红细胞、血小板、血清谷丙转氨酶、肌酐、尿素氮等均无影响,值得推广应用。
Ranitidiue is a new generation of histamine (H 2) receptor blocker synthesized after cimetidine in recent years, which can significantly inhibit gastric acid secretion and have a significant effect on duodenal ulcer . Tang Chengwei, the first hospital of our school, treated 169 cases of duodenal ulcer with homemade furanitamide (Chongqing Institute of Pharmaceutical Industry) for the first time. The daily dosage was 300mg (150mg twice daily) for 6 weeks. The endoscopic observation, the effect was significantly better than cimetidine daily 1000mg (200mg three times a day, 400mg once night), the healing rates were 89% and 69% (P <0.01). Clinical application also shows that side effects of nitrofuranthamine than cimetidine less short-term use of white blood cells, red blood cells, platelets, serum alanine aminotransferase, creatinine, urea nitrogen and so have no effect, it is worth promoting the application.