论文部分内容阅读
1982年7月～1984年3月,作者把238名HBsAg阳性母亲的婴儿随机分成两组,Ⅰ组117人,Ⅱ组121人。Ⅰ组于出生后2小时注射乙型肝炎免疫球蛋白(HBIG)200U,并按0、1、2、11月接种血源HB疫苗10μg;Ⅱ组于0、3月各注射HBIG 200U和125U,按3、4、5、11月程序接种血源HB疫苗10μg。1984年4月～1987年11月,257名婴儿随机分入Ⅲ组(133人)和Ⅳ组(124人),两组均于0月注射HBIG 200U,并按0、1、6月程序分别接种血源HB疫苗10μg(Ⅲ组)和5μg(Ⅳ组)。1988年1月～1989年10月,将210名HBsAg阳性母亲的婴儿随机分至Ⅴ组(112人)和Ⅵ组(98人)两组均于出生后2小时内注射HBIG 300U,Ⅵ组于3月龄时加注300U,Ⅴ、Ⅵ组均按3、4、5、11月接种重组HB疫苗20μg。
From July 1982 to March 1984, 238 infants of HBsAg-positive mothers were randomized into two groups: group I with 117 and group II with 121. Group Ⅰ was injected with 200U of hepatitis B immunoglobulin (HBIG) 2 hours after birth and 10 μg of HB vaccine was inoculated on days 0, 1, 2, and November; group Ⅱ was injected with 200U and 125U of HBIG in each of 0 and March, According to 3, 4, 5, November program vaccination of blood HB vaccine 10μg. From April 1984 to November 1987, 257 infants were randomized into Group Ⅲ (133) and Group Ⅳ (124). Both groups were given HBIG 200U at 0 month intervals and were divided into two groups according to the procedures of 0, 1 and 6 months Inoculated with blood HB vaccine 10μg (Ⅲ group) and 5μg (Ⅳ group). From January 1988 to October 1989, 210 HBsAg-positive mothers were randomly divided into Group V (112) and Group VI (98) infants were injected with HBIG 300U within 2 hours after birth. Group Ⅵ At 3 months of age, 300U were injected. Groups Ⅴ and Ⅵ were vaccinated with recombinant HB vaccine at doses of 3, 4, 5 and 11 months.