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目的 :探讨迷走神经是否可以作为LPS信息由外周组织传入中枢神经系统的桥梁。方法 :将Wistar大鼠随机分组 ,实验组为膈下迷走神经切断并给予LPS组 ,三个对照组为假手术生理盐水组 ,假手术LPS组 ,膈下迷走神经切断生理盐水组。用数字体温检测仪测定大鼠体温。用玻璃微电极记录正常大鼠和膈下迷走神经切断大鼠给予LPS前后下丘脑室旁核的单位放电。结果 :体温变化 :实验组大鼠体温变化值与假手术LPS组相比明显降低 (P <0 .0 5 )。单位放电变化 :正常大鼠给予LPS后室旁核单位放电放电频率明显增加 ,膈下迷走神经切断大鼠给予LPS后室旁核单位放电频率无明显变化。结论 :外周LPS信息可能通过迷走神经传递到脑组织
Objective: To investigate whether vagal nerve can be used as a bridge between the LPS information and the central nervous system. Methods: Wistar rats were randomly divided into three groups. The experimental group was subcutanous vagotomy and the LPS group was given. The three control groups were sham-operated saline group, sham-operated LPS group and subdiaphragmatic vagotomy. Rat body temperature was measured by digital temperature detector. The unit discharge of hypothalamic paraventricular nucleus before and after LPS administration in normal rats and subdiaphragmatic vagotomy rats was recorded by glass microelectrode. Results: The changes of body temperature: The changes of body temperature in experimental group were significantly lower than those in sham-operated LPS group (P <0.05). Unit discharge changes: normal rats given LPS after paraventricular nucleus unit discharge frequency was significantly increased, subdiaphragmatic vagotomy rat LPS after paraventricular nucleus unit discharge frequency did not change significantly. CONCLUSIONS: Peripheral LPS information may be delivered to the brain through the vagus nerve