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细胞免疫在防御外来病原感染、自身免疫及肿瘤等疾病中发挥重要作用。随着分子免疫学研究的不断发展,对T淋巴细胞免疫分子机制的阐释,大量T细胞表位信息以及功能基因组学资料的积累,使得基于数据驱动的预测T细胞表位的研究受到重视,可能成为疫苗研发的重要工具之一。本文概述辅助T细胞表位预测的理论和方法及其在寄生虫疫苗研发中的应用,并讨论未来的研究方向。
Cellular immunity plays an important role in defense against diseases such as foreign pathogens, autoimmunity and tumors. With the development of molecular immunology, the elucidation of the molecular mechanism of T lymphocyte immunity, the accumulation of a large number of T cell epitope information and the accumulation of functional genomics data have drawn attention to the research of data-driven prediction of T cell epitopes, Become one of the important tools for vaccine development. This article provides an overview of theories and methods for predicting helper T cell epitopes and their applications in the development of parasite vaccines and discusses future directions for their research.