由于金黄色葡萄球菌 A 蛋白能与大多数哺乳类动物的免疫球蛋白(主要是 IgG)相互作用,在免疫技术中已成为一种重要的试剂。福尔马林固定的金葡菌可提供一种能与 IgG 相互作用的固相结合的SPA,这种 SPA 甚至在储藏数月后仍不变性。最初人们用此试剂作协同凝集试验来进行细菌的血清学分群,目前已用在放射免疫测定及细胞膜抗原的免疫沉淀试验,作为一种固相的抗-IgG 试剂,并可用来检出和分离淋巴细胞,以及作为特异的 B 细胞促分裂素。 Since S. aureus protein A interacts with immunoglobulins (mainly IgG) in most mammals, it has become an important reagent in immunization. Formalin-immobilized Staphylococcus aureus provides a solid-phase-bound SPA that interacts with IgG, a SPA that is not denatured even after several months of storage. Initially, the serological grouping of bacteria was carried out using this reagent as a cohesive agglutination test and has now been used in radioimmunoassay and immunoprecipitation of cell membrane antigens as a solid-phase anti-IgG reagent and for the detection and isolation Lymphocytes, and as specific B-cell mitogen.