对腹主动脉瘤死亡率筛查的影响:人群随机对照试验

来源 :世界核心医学期刊文摘(心脏病学分册) | 被引量 : 0次 | 上传用户:mokung1
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Objective: To assess whether screening for abdominal aortic aneurysms in men r educes mortality. Design: Population based randomised controlled trial of ultras ound screening, with intention to treat analysis of age standardised mortality. Setting: Community based screening programme in Western Australia. Participants: 41 000 men aged 65-83 years randomised to intervention and control groups. Int ervention: Invitation to ultrasound screening. Main outcome measure: Deaths from abdominal aortic aneurysm in the five years after the start of screening. Resul ts: The corrected response to invitation to screening was 70%. The crude preval ence was 7.2%for aortic diameter ≥.30 mm and 0.5%for diameter ≥.55 mm. Twice as many men in the intervention group than in the control group underwent elect ive surgery for abdominal aortic aneurysm(107 v 54, P=0.002, χ2 test). Between scheduled screening and the end of follow up 18 men in the intervention group an d 25 in the control group died from abdominal aortic aneurysm, yielding a mortal ity ratio of 0.61(95%confidence interval 0.33 to 1.11). Any benefit was almost entirely in men aged between 65 and 75 years, where the ratio was reduced to 0.1 9(0.04 to 0.89). Conclusions: At a whole population level screening for abdomina l aortic aneurysms was not effective in men aged 65-83 years and did not reduce overall death rates. The success of screening depends on choice of target age g roup and the exclusion of ineligible men. It is also important to assess the cur rent rate of elective surgery for abdominal aortic aneurysm as in some communiti es this may already approach a level that reduces the potential benefit of popul ation based screening. Objective: To assess whether screening for abdominal aortic aneurysms in men r educes mortality. Design: Population based randomized controlled trial of ultrasound screening, with intention to treat analysis of age standardized mortality. Setting: Community based screening program in Western Australia. Participants: 41 000 men aged 65-83 years randomized to intervention and control groups. Int ervention: Invitation to ultrasound screening. Main outcome measure: Deaths from abdominal aortic aneurysm in the five years after the start of screening. Resul ts: The corrected response to invitation The crude preval ence was 7.2% for aortic diameter ≥.30 mm and 0.5% for diameter ≥ 0.55 mm. Twice as many men in the intervention group than in the control group underwent elect ive surgery for abdominal aortic aneurysm (107 v 54, P = 0.002, χ 2 test). Between scheduled screening and the end of follow up 18 men in the intervention group an d 25 in the control group died from a biliary aortic aneurysm, yielding a mortal ity ratio of 0.61 (95% confidence interval 0.33 to 1.11). Any benefit was almost entirely between men aged 65 and 75 years, where the ratio was reduced to 0.1 9 (0.04 to 0.89). Conclusions : At a whole population level screening for abdomina l aortic aneurysms was not effective in men aged 65-83 years and did not reduce overall death rates. The success of screening depends on choice of target age g roup and the exclusion of ineligible men. It is also important to assess the cur rent rate of elective surgery for abdominal aortic aneurysm as in some communiti es this may already approach a level that reduces the potential benefit of popultion based screening.
其他文献
Background: The association between the presence of diagonal earlobe crease (ELC) and coronary artery disease (CAD) still remains controversial. Objective: The
本刊讯(记者 戈 壁):以“展示、交流、合作、发展”为主题的中国职业教育成果展示会·第二届中国职业教育装备展示会暨第四届中国长春国际教育展览会,以及全国中等职业学校学生
Abstract Hyperpolarization-activated cyclic-nucleotide-gated ( HCN) channels in the heart modulate cardiac automaticity via the hyperpolarization-activated cati
为满足实际生产的需要,节省工时,需设计一种高位自卸汽车,文中阐述了高位自卸汽车的设计要求,设计方案分析,设计方案选择,并绘制了设计的机构简图。 In order to meet the n
左室肥厚(LVH)的高血压患者常常舒张功能受损害而收缩功能正常;左室缩短分数(FS)正常或超正常的高血压患者左室壁内机械可能已受损害,但左室舒张功能受损是否与收缩力抑制及
在应用“启发—探究”教学模式时要适合小学生的认知规律,把大问题细化成一个个小问题,从而更好地发展学生的语言能力。 In the application of “enlightening - inquiry
患者,男,35岁.因发热、咳嗽、头痛、视物障碍1个半月入院.入院前1个半月因着凉后出现发热、咳嗽、咽痛,自服感冒药,病情无好转,体温升至39℃,并出现视物模糊.到当地医院查:双侧扁桃体Ⅱ度肿大,有脓点,左侧视野同向偏盲,心肺无异常,其他神经系统检查正常.头CT检查示右侧枕叶出血,头部MRI检查未见异常;凝血功能检查正常.手术清除血肿,并抗感染、止血、降颅压治疗.但仍发热,颈胸部皮肤出现出血点,体温
考点一 only修饰不定式表结果  only 后接不定式作状语时,有时表示目的,有时表示结果(尤其表示让人没有事先想到或令人感到不快的意外结果)。如:  Not content with second place, Jeff played only to win. 杰夫不甘心得第二名,他参加比赛就是为了夺冠。(句中的only to win表目的)  He rushed to the airport
桑植位于湖南省西北边陲,是一个革命老区县,又是一个民族文化大县,以土家族、白族为主的少数民族占总人口的92.6%,各个民族在相互交流的过程中,相互学习,共同进步,积淀了深厚
BACKGROUND: The risk of sudden death from cardiac causes is increased among survivors of acute myocardial infarction with reduced left ventricular systolic func