The difference analysis of physical-mechanical properties of muddy sediments is made in the central South Yellow Sea and the Zhe-Min(Zhejiang Province to Fujian Province of China) coastal area. The results show that sediments in the two regions are both dominated by mud. There are perfect negative power function correlations between the water content and the density, the compression coefficient and the compression modulus; a good positive power function correlation between the liquid limit and the plastic limit, a perfect positive linear correlation between the water content and the void ratio, and a perfect polynomial function correlation between the miniature vane shear strength and the pocket penetration resistance. In general, compared with sediments in the Zhe-Min coastal area, sediments in the central South Yellow Sea possess high water content, high void ratio,low density, high plasticity, high compressibility, low shear strength. The causes of the differences between physical-mechanical properties of sediments are analyzed from the topographic features, material sources,hydrodynamic conditions, deposition rate, and material composition. Compared with the Zhe-Min coastal area,the central South Yellow Sea is far from the Mainland and low-lying; has poor hydrodynamic condition; the materials diffused to the area are less and dominated by fine clay, have the high content of smectite and organic matters. These factors lead to sediments of the central South Yellow Sea has the higher water content, the higher plasticity, the lower density, and the lower strength than sediments in the Zhe-Min coastal area. The difference analysis of physical-mechanical properties of muddy sediments is made in the central South Yellow Sea and the Zhe-Min (Zhejiang Province to Fujian Province of China) coastal area. The results show that sediments in the two regions are both dominated by mud There are perfect negative power function correlations between the water content and the density, the compression coefficient and the compression modulus; a good positive power function correlation between the liquid limit and the plastic limit, a perfect positive linear correlation between the water content and the void ratio, and a perfect polynomial function correlation between the miniature vane shear strength and the pocket penetration resistance. in general, compared with sediments in the Zhe-Min coastal area, sediments in the central South Yellow Sea posse high water content, high void ratio , low density, high plasticity, high compressibility, low shear strength. The causes of the differences between physical-m Compared with the Zhe-Min coastal area, the central South Yellow Sea is far from the Mainland and low-lying; has poor hydrodynamic condition; the materials diffused to the area are less and dominated by fine clay, have the high content of smectite and organic matters. the factors lead to sediments of the central South Yellow Sea has the higher water content, the higher plasticity, the lower density, and the lower strength than sediments in the Zhe-Min coastal area.