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目的研究尿结缔组织生长因子(CTGF)与糖尿病肾病肾损伤的相关性,评价其在糖尿病肾病肾损伤诊断中的诊断价值。方法分别检测48例健康体检者、97例糖尿病肾病患者(其中A组为正常蛋白尿38例,B组为微量蛋白尿29例,C组为临床蛋白尿30例)尿结缔组织生长因子水平。对照组来自本院健康体检人群。采用ELISA法检测尿结缔组织生长因子水平,同时检测TG、SCr、GHb、TC及BUN等指标。结果病例组患者尿CTGF平均含量为(50.12±43.32)ng/mg,明显高于对照组尿CTGF平均含量(4.41±2.23)ng/mg,组间比较差异有统计学意义(P<0.05);3组病例组之间比较发现,蛋白尿水平越高,尿CTGF含量增加越明显。C组尿CTGF含量为(112.24±45.59)ng/mg,明显高于A、B两组(P<0.05);Pearson’s相关性分析结果显示:尿CTGF水平与血清UAE水平呈明显正相关(r=0.721,P<0.05)。结论结缔组织生长因子与糖尿病肾病的发生关系密切,尿结缔组织生长因子水平在DN肾损伤诊断中有一定的临床应用价值。
Objective To study the correlation between urinary connective tissue growth factor (CTGF) and diabetic nephropathy and to evaluate its diagnostic value in the diagnosis of diabetic nephropathy. Methods Urine connective tissue growth factor was detected in 48 healthy subjects and 97 diabetic nephropathy patients (group A, n = 38, group B, microalbuminuria, group C, clinical proteinuria, respectively). Control group from the hospital health examination population. The levels of urinary connective tissue growth factor were detected by ELISA, and the indexes of TG, SCr, GHb, TC and BUN were also detected. Results The urinary CTGF level in the patients was significantly higher than that in the control group (50.12 ± 43.32) ng / mg, which was significantly higher than that in the control group (4.41 ± 2.23) ng / mg. There was significant difference between the two groups (P <0.05). Comparisons among the three groups showed that the higher the level of proteinuria, the more obvious the increase of urinary CTGF. The urinary CTGF level in group C was (112.24 ± 45.59) ng / mg, which was significantly higher than that in group A and B (P <0.05). Pearson’s correlation analysis showed that urinary CTGF level was positively correlated with serum UAE level (r = 0.721, P <0.05). Conclusions Connective tissue growth factor is closely related to the occurrence of diabetic nephropathy. The level of urinary connective tissue growth factor has some clinical value in the diagnosis of DN renal injury.