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目的:评价诱导性一氧化氮合酶(iNOS)抑制药氨基胍(AG)的抗感染性休克作用。方法:杂种犬(8～12kg)2小时内静滴内毒素(LPS,1mg/kg)后随机分为对照(n=6)和治疗组。治疗组在MAP下降后2小时分别静注L-N-位硝基精氨甲酯(L-NAME,n=6,30mg/kg)和AG(n=6,20mg/kg)。结果:静注LPS后1小时在NO升高同时MAP明显下降,SVR和尿量明显减少。给予L-NAME后,MAP、MPAP、CVP和SVR明显升高,CO和HR明显减少(P<0.05),尿量无明显增加。静注AG后MAP、SVR和尿量明显增加(P<0.05),而CVP、PAP、CO和HR无明显改变。结论:感染性休克中NO明显增加,AG对循环功能的改善好于L-NAME。
OBJECTIVE: To evaluate the anti-infective shock effect of iNOS inhibitor aminoguanidine (AG). Methods: The dogs were randomly divided into control (n = 6) and treatment groups after intravenous infusion of endotoxin (LPS, 1 mg / kg) within 2 hours. L-NAME (n = 6, 30 mg / kg) and AG (n = 6, 20 mg / kg) were intravenously administered to the treatment group 2 hours after the decrease in MAP. Results: After 1 hour of intravenous injection of LPS, MAP increased significantly while NO increased, while SVR and urine output decreased significantly. After administration of L-NAME, MAP, MPAP, CVP and SVR were significantly increased, CO and HR were significantly reduced (P <0.05), urine output was not significantly increased. After intravenous injection of AG, MAP, SVR and urine output increased significantly (P <0.05), while CVP, PAP, CO and HR had no significant changes. Conclusion: The NO in septic shock increased significantly, and the improvement of circulatory function by AG was better than L-NAME.