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目的探讨绝经后冠心病患者雌激素、凝血及纤溶系统的变化及保健措施。方法选取2011年3月-2013年3月收治的正常绝经≥1年,因胸痛就诊的78例患者为研究对象,根据冠状动脉造影结果将患者分为冠心病组(36例)与非冠心病组(42例),测定两组患者空腹状态下血雌激素水平、凝血及纤溶系统指标。结果与非冠心病组比较,冠心病组孕酮及雌二醇水平明显降低(P<0.05),黄体生成素(LH)和卵泡刺激素(FSH)水平明显升高(P<0.05),凝血系统中的纤维蛋白原及血管性血友病因子抗原(v WF∶Ag)水平明显升高(P<0.05),纤溶系统中的组织纤溶酶原激活剂(t-PA)水平明显降低(P<0.05),纤溶酶原激活物抑制物-1(PAI-1)水平明显升高(P<0.05)。结论与绝经后非冠心病患者相比,绝经后冠心病患者雌二醇水平明显降低,凝血功能亢进、纤溶功能下降,需采取相应的保健措施进行干预。
Objective To investigate the changes of estrogen, coagulation and fibrinolysis system in postmenopausal women with coronary heart disease and their health care measures. Methods A total of 78 patients with chest pain who were admitted to our hospital from March 2011 to March 2013 were enrolled in this study. According to coronary angiography, patients were divided into coronary heart disease group (36 cases) and non-coronary heart disease (N = 42). The levels of blood estrogen, coagulation and fibrinolytic system were measured in both groups. Results Compared with non-CHD group, the levels of progesterone and estradiol in CHD group were significantly lower (P <0.05), the levels of LH and FSH were significantly increased (P <0.05) The levels of fibrinogen and vWF: Ag in the system were significantly increased (P <0.05), and the levels of tissue plasminogen activator (t-PA) in the fibrinolytic system were significantly decreased (P <0.05) and PAI-1 (P <0.05). Conclusion Compared with patients with non-CHD after menopause, estradiol levels in patients with postmenopausal coronary heart disease were significantly decreased, coagulation function and fibrinolysis function decreased, and corresponding health care measures should be taken for intervention.