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目的:观察乙酰半胱氨酸联合细辛脑治疗慢性阻塞性肺病加重期的疗效。方法:选择慢性阻塞性肺疾病加重期患者220例,随机分为治疗组110例,对照组110例。两组均给予氨溴索30mg 2/日,多索茶碱0.1 2/日,同时据药敏或经验选择抗生素。治疗组在此基础上给予乙酰半胱氨酸0.6 1/日,细辛脑16mg静点1/日。治疗期间观察不吸氧的情况下脉氧的指数、血气分析氧分压、二氧化碳分压及PH值的改变,和好转率、住院天数的改变。结果:治疗组较对照组的好转率明显提高,平均住院天数缩短。结论:慢性租塞性肺病急性发作期患者在常规药物治疗的同时联合应用乙酰半胱氨酸和细辛脑治疗疗效显著,提高了慢性阻塞性肺病加重期的好转率,缩短住院时间,减少住院费用。
Objective: To observe the effect of acetylcysteine combined with asarone on patients with exacerbation of chronic obstructive pulmonary disease. Methods: A total of 220 patients with exacerbation of chronic obstructive pulmonary disease were randomly divided into treatment group (n = 110) and control group (n = 110). Both groups were given ambroxol 30mg 2 / day, doxofylline 0.1 2 / day, at the same time, antibiotics were selected according to susceptibility or experience. The treatment group was given on the basis of acetylcysteine 0.6 1 / day, asarone 16mg static point 1 / day. During treatment, the index of pulse oxygen, oxygen partial pressure of blood gas analysis, change of partial pressure of carbon dioxide and PH value, and rate of improvement and length of hospital stay were observed. Results: The improvement rate of treatment group was significantly higher than that of control group, and the average hospitalization days were shortened. Conclusions: Patients with acute exacerbation of chronic obstructive pulmonary disease treated with acetylcysteine and asarone in combination with conventional medical therapy have remarkable curative effect, which improves the improvement rate of exacerbation of COPD, shorten the hospitalization time and reduce the hospitalization cost.