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目的：寻找肾上腺素用于心肺复苏的最佳剂量。方法：选择成年杂种犬６０条，随机分为６组，造成心梗模型后致颤，分别给予０．０２、０．０５、０．０７５、０．１、０．２、０．３ｍｇ／ｋｇ体重的肾上腺素进行心肺复苏，比较心肺复苏的成功率，恢复自主循环的时间及自主循环恢复１ｍｉｎ后血流动力学指标的变化；并以电镜技术观察肾上腺素对心肌组织的影响。结果：０．０７５ｍｇ／ｋｇ和０．１ｍｇ／ｋｇ体重组复苏的成功率明显高于其他各组（Ｐ＜０．０５），且此两组自主循环的恢复时间明显短于其他各组（Ｐ＜０．０５）；各组复苏１ｍｉｎ后血流动力学指标的变化：随着剂量的增加，收缩压、舒张压、左室收缩末压逐渐增加，但心输出量和冠脉血流量却在０．０７５ｍｇ／ｋｇ体重组达最高，与其他各组比较Ｐ值均＜０．０５，超过０．１ｍｇ／ｋｇ心输出量和冠脉血流量不再继续增加；电镜所见：各组非梗塞区的心肌组织只有轻微改变，与所用的肾上腺素的剂量无关。结论：犬心肺复苏过程中应用０．０７５ｍｇ／ｋｇ和０．１ｍｇ／ｋｇ体重的肾上腺素为最佳剂量
Objective: To find the best dose of epinephrine for cardiopulmonary resuscitation. Methods: Sixty adult crossbred dogs were randomly divided into 6 groups, which caused defibrillation after myocardial infarction model and were given 0.02,0.05,0.075,0.1,0.2,0.3mg / kg Body weight of epinephrine cardiopulmonary resuscitation, compared the success rate of cardiopulmonary resuscitation, recovery of spontaneous circulation time and autonomic circulation after 1min hemodynamic changes; and electron microscopy of epinephrine on myocardial tissue. Results: The success rates of resuscitation in 0.075mg / kg body weight and 0.1mg / kg body weight group were significantly higher than those in other groups (P <0.05), and the recovery time of spontaneous circulation in these two groups was significantly shorter than that in other groups <0.05). The changes of hemodynamics after 1 minute resuscitation: the systolic blood pressure, diastolic blood pressure and left ventricular end-systolic pressure increased gradually with the increase of dose, but the cardiac output and coronary blood flow were 0.075mg / kg body weight of the highest group, compared with other groups P values were <0.05, more than 0.1mg / kg cardiac output and coronary blood flow no longer continue to increase; electron microscopy: each group of non-infarction Myocardial tissue in the area has only minor changes, irrespective of the dose of epinephrine used. Conclusion: The optimal dose of epinephrine 0.075mg / kg and 0.1mg / kg body weight in canine cardiopulmonary resuscitation