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目的 :研究肺耐药蛋白 (LRP)在人恶性黑色素瘤转移性淋巴结组织中的表达及其与以顺铂、氮烯咪胺为主的联合化疗 (PDBV)疗效的关系。方法 :免疫组织化学技术对石蜡包埋组织标本进行检测。结果 :2 6例晚期恶性黑色素瘤患者转移性淋巴结组织中LRP表达阳性检出率为 69.2 % ( 18/2 6)。而LRP阳性表达者化疗有效率明显低于阴性者 (P <0 .0 5 )。结论 :LRP在人恶性黑色素瘤转移性淋巴结组织中有一定程度表达 ,检测LRP表达对临床用药的指导可能有意义。
Objective: To investigate the expression of lung resistance protein (LRP) in human malignant melanoma metastatic lymph nodes and its relationship with cisplatin and prednisolone combined with chemotherapy (PDBV). Methods: Immunohistochemistry was used to detect paraffin-embedded tissue specimens. Results: The positive rate of LRP expression in metastatic lymph nodes in 26 patients with advanced malignant melanoma was 69.2% (18/2 6). The effective rate of chemotherapy in LRP positive patients was significantly lower than that in negative ones (P <0.05). CONCLUSION: LRP is expressed in metastatic lymph node tissue of human malignant melanoma to some extent. It may be meaningful to detect the expression of LRP in clinical medication.