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目的观察应用金芪降糖片对2型糖尿病一级亲属中糖耐量受损(IGF)患者的疗效。方法 2型糖尿病一级亲属中糖耐量受损患者100例,随机分为对照组和治疗组,各50例。对照组指导控制饮食和运动治疗,改善原生活方式,疗程12个月;治疗组在控制饮食和运动治疗的基础上给予金芪降糖片,3次/d,2片/次,疗程12个月。观察两组治疗前后血糖、胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)等指标的变化。结果治疗后,两组血糖、HOMA-IR、HOMA-β较治疗前均有改善,差异均有统计学意义(P<0.05);治疗后治疗组血糖、HOMA-IR、HOMA-β指标改善均优于对照组(P<0.05);治疗组糖尿病转化率2%,对照组糖尿病转化率12%,组间比较差异有统计学意义(P<0.05)。结论金芪降糖片能显著改善糖代谢、胰岛素抵抗、胰岛β细胞功能,可减少糖耐量受损向糖尿病的转化,具有临床应用价值。
Objective To observe the effect of Jinqijiangtang tablet on patients with impaired glucose tolerance (IGF) in first-degree relatives of type 2 diabetes mellitus. Methods 100 cases of impaired glucose tolerance in first-degree relatives of type 2 diabetes were randomly divided into control group and treatment group, 50 cases each. The control group guided diet and exercise therapy to improve the original lifestyle, the course of treatment was 12 months. The treatment group was given Jinqi hypoglycemic tablets on the basis of diet and exercise control, 3 times / d, 2 tablets / time, 12 month. The changes of blood glucose, insulin resistance index (HOMA-IR) and islet β-cell function index (HOMA-β) before and after treatment were observed. Results After treatment, the levels of blood glucose, HOMA-IR and HOMA-β in both groups were significantly improved compared with those before treatment (all P <0.05). After treatment, the blood glucose, HOMA-IR and HOMA- (P <0.05). In the treatment group, the conversion rate of diabetes was 2% and that of the control group was 12%. The differences between the two groups were statistically significant (P <0.05). Conclusion Jinqi hypoglycemic tablets can significantly improve glucose metabolism, insulin resistance, pancreatic β-cell function, can reduce the impaired glucose tolerance to diabetes conversion, with clinical value.