高校实验教学中心是进行实验教学和开展科学研究的重要基地。通过分析新时期高校实验教学中心的新特点以及存在的问题，结合湖南科技大学电子与电气技术国家级实验教学中心安全工作的具体实践，坚持“安全第一”、“以人为本，预防为主”的方针，提出了从领导重视、队伍建设、管理制度、安全教育和实验中心的信息化建设等五个方面构建实验安全保障体系。“,”The experimental teaching center is an important base for carrying out experimental teaching and scientific research.In this paper,the present situation,new characteristics,and existing problems of safety management of experimental teaching center are analyzed under the new situation.The authors analyze the concrete practice of safety management in electronics and electrical technology national experimental teaching center of Hunan University of Science and Technology,which adheres to the policy of“safety first,human-oriented and precaution crucial”,and puts forward to establishing safety guarantee system of the experimental teaching center from five aspects: leaders\'attention,teachers’team construction,management system, safety education and information construction of the experimental teaching center.