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异菸肼(INH)是最常用的抗结核病药之一,但是剂量过大时可致严重中毒,出现精神失常、共济失调、惊厥和癫痫发作,甚至死亡。据报道,本品是一种较常用的自杀药物,例如在某些印第安人居住区,此类病例占自杀住院数的50%。抢救INH急性中毒时,一般常用维生素B_6,然而疗效很不确实,近来还发现,给大白鼠脑室内注射磷酸吡哆醛可诱发惊厥。本文发现,维生素B_6的另一种化合物盐酸吡哆辛(简称B_6)能增强急性中毒的小白鼠的毒性反应,而安定(DZ)有对抗作用,兹报道如下:
Isoniazid (INH) is one of the most commonly used anti-tuberculosis drugs, but it can cause severe poisoning when given in excessively large doses, causing insanity, ataxia, convulsions and seizures, and even death. It is reported that this product is a more commonly used suicide drug, for example in some Indian settlements, such cases account for 50% of suicide hospitalizations. Rescue INH acute poisoning, the commonly used vitamin B_6, but the effect is very accurate, recently also found that intracerebral injection of pyridoxine phosphate can induce seizures. This paper found that another compound of vitamin B_6 pyridoxine hydrochloride (referred to as B_6) can enhance the toxicity of acute poisoning in mice, and diazepam (DZ) have antagonistic effect, it is reported as follows: