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在大鼠以强电刺激外周感受野诱发的脊髓背角ＷＤＲ和ＮＳ神经元的晚串放电（Ｃ－反应）作为伤害感受性反应，观察了双侧丘脑中央下核（Ｓｍ）或顶盖前区前核（ＡＰｔＮ）内微量注射局麻药利多卡因对不同强度电针引起的镇痛效应的影响。结果表明：双侧Ｓｍ局麻可明显减弱强电针对Ｃ－反应的抑制效应，但对弱电针的抑制效应无明显影响；双侧ＡＰｔＮ局麻可明显减弱弱电针对Ｃ－反应的抑制效应，但对强电针的抑制效应无明显影响。结果提示，不同强度的电针刺激可能由粗细不同的纤维传入，通过不同的中枢机制产生镇痛作用。Ｓｍ参与介导强电针兴奋细纤维产生的镇痛作用；ＡＰｔＮ则参与介导弱电针兴奋粗纤维产生的镇痛作用。
Lateral discharge (C-reaction) of spinal dorsal horn WDR and NS neurons induced by intense electrical stimulation in peripheral receptive field was used as nociceptive response to observe the effects of bilateral hypothalamic subnucleus (Sm) or apical region Effect of microinjection of local anesthetic lidocaine into APtN on the analgesic effect induced by electroacupuncture at different intensities. The results showed that both sides of the Sm local anesthesia can significantly reduce the strong electro-acupuncture on the C-response inhibition effect, but the weak electro-acupuncture inhibitory effect had no significant effect; bilateral APtN local anesthesia can weaken weak electric acupuncture inhibition of C-response, but The inhibitory effect of strong electro-acupuncture had no significant effect. The results suggest that electro-acupuncture at different intensities may be introduced by different thickness fibers and produce analgesic effects through different central mechanisms. Sm participates in mediating the analgesic effect of EAF excited by fine fibers; APtN participates in the analgesic effect induced by weak electro-acupuncture stimulation of crude fibers.