上个世纪50年代,Yamada用电子显微镜观察到细胞膜上存在许多烧瓶状的小凹结构,并命名为细胞质膜微囊(Caveo-lae)。在随后的几十年中,这个囊泡样的结构虽然引起了许多学者极大的兴趣,但对其构成成分以及功能的研究仍然不深入;这种状况一直到Caveolin被发现后才有改变。1980年,有研究者发现用v-Src癌基因转化鸡胚胎成纤维细胞时,有一个蛋白能 In the 1950s, Yamada observed by electron microscopy many flask-shaped concave structures on the cell membrane and was named Caveo-lae. In the ensuing decades, this vesicular-like structure has drawn great interest from many scholars. However, the research on its composition and function is still not deep; this situation did not change until Caveolin was discovered. In 1980, some researchers found that when v-Src oncogene was used to transform chicken embryo fibroblasts, there was a protein