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目的：进一步了解不同剂量善得定对门静脉压力乃至全身血流动力学的影响，探讨其降低门静脉压力的机理。方法：正常大鼠中静脉内注入不同剂量善得定，并持续２０ ｍ ｉｎ 动态观测门静脉压力、平均动脉压力、腔静脉压力和心率的变化。然后静脉内注入４８ μｇ 异丙肾上腺素或３０ μｇ 苄胺唑啉，再持续５ ｍ ｉｎ 观测上述各指标的变化，以探讨善得定降低门静脉压力的作用机理。结果：应用不同剂量善得定后１ ｍ ｉｎ，门静脉压力均明显下降（ Ｐ＜ ０００１），至用药后２０ ｍ ｉｎ 仍保持下降趋势，其变化与善得定剂量呈高度负相关（ｒ＝ － ０５０１， Ｐ＜ ０００５）；用药后动脉压力升高，其程度与善得定剂量呈高度正相关（ｒ＝ ０２７６， Ｐ＜ ００５）；各善得定组的心率和腔静脉压力均无明显变化（ Ｐ＞ ００５）；后期静脉内注入等量苄胺唑啉后，各组动物的动脉压力均迅速而明显下降，１ ｍ ｉｎ 时达低谷，随后又较快回升，其动脉压力变化与前期应用善得定剂量呈高度正相关（ｒ＝ ０７４７， Ｐ＜ ００１）。结论：善得定降低门静脉压力的机理主要是通过兴奋 α受体，使腹腔内脏小动脉收缩，门静脉系血液流入量减少的结果。
OBJECTIVE: To further understand the effects of different doses of good-to-be-fixed on portal pressure and systemic hemodynamics and to explore the mechanism of lowering portal pressure. Methods: Normal rats were injected intravenously with different dosages of propofol, and the changes of portal pressure, mean arterial pressure, vena cava pressure and heart rate were observed dynamically for 20 minutes. Then intravenous injection of 4 8 g isoproterenol or 30 μg of benzylazoline, and then continued for 5 m in observed changes in the above indicators in order to explore the sclerotherapy to reduce the role of portal pressure mechanism. Results: After 1 min in different dosages, portal pressure was significantly decreased (P <0001), and maintained a downward trend 20 minutes after administration. The change was negatively correlated with the dosage of = -0501, P <0005). The arterial pressure increased after treatment, the degree of which was positively correlated with the dosage of ZD (r = 0276, P <005) Heart rate and vena cava pressure had no significant change (P> 0 05); late intravenous injection of equal amount of benzylazoline, the arterial pressure of each group of animals were rapidly and significantly decreased, reached a low at 1 m in, then And a faster recovery. The changes of arterial pressure were positively correlated with the dosage of ZD (r = 0747, P <001). Conclusion: The mechanism of Decrease of portal vein pressure is mainly through the excitement of α receptor, the contraction of visceral visceral arterioles, portal blood flow decreased.