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乙型肝炎病毒(HBV)属于DNA病毒。Kaplan亦证明Dane颗粒的核心内含有双链DNA和专一性DNA聚合酶(DNA Polymerase,DNA-P)。此Dane颗粒乃完整的HBV颗粒。乙型肝炎患者在潜伏期的后一阶段,血清中出现乙型肝炎表面抗原(HBsAg)的同时,并在临床发病及转氨酶(GPT)上升前,便可检出DN-A-P活力。DNA-P活力的高峰出现在HBsAg最高滴度之前。当GPT上升时,DNA-P活力则下降。一般急性肝炎患者DNA-P活力的升高可持续几天至几周。但急性乙型肝炎有演变为慢性肝炎者可持续1～3个月。慢性HBs-Ag携带者,其血清DNA-P活力的升高可持续几个月至几年。因此,目前国内外均已应用DNA-P活力的测定,以观察HBV复制程度,和确定HBsAg携带者有否传染性的可靠方法之一。
Hepatitis B virus (HBV) is a DNA virus. Kaplan also demonstrated that Dane particles contain double-stranded DNA and DNA Polymerase (DNA-P) in their core. This Dane particle is a complete HBV particle. Hepatitis B patients detect DN-A-P activity at the same time as serum hepatitis B surface antigen (HBsAg) appears later in the incubation period and before clinical onset and increase in transaminase (GPT). The peak of DNA-P activity preceded the highest HBsAg titer. As GPT increases, DNA-P activity decreases. General acute hepatitis DNA-P activity increased for several days to several weeks. However, acute hepatitis B has evolved into chronic hepatitis who may last 1 to 3 months. Chronic HBs-Ag carriers, the increase of serum DNA-P activity can last from several months to several years. Therefore, at present, the determination of DNA-P activity has been applied both at home and abroad to observe the degree of HBV replication and one of the reliable methods to determine whether HBsAg carriers are contagious.