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目的：探讨早期床旁血液灌流（HP）治疗急性重度中毒的疗效。方法：回顾性分析2007年1月－2015年6月我院急诊收治的在确诊后1．5 h内应用HP联合常规内科治疗的急性重度中毒患者65例的临床资料，比较治疗前和治疗后24 h血常规、血气分析、肝肾心功能及凝血功能及急性生理和慢性健康状况评分（APACHEⅡ）。结果：治疗前后患者的血pH、血小板（PLT）、血红蛋白（HB）和钾（K＋）值均明显改善（P＜0．05）， APACHEⅡ评分明显降低（P＜0．05），二氧化碳分压（PaCO2）、谷丙转氨酶（ALT）、谷草转氨酶（AST）、白蛋白（ALB）、肌酐（Cr）、肌酸激酶同工酶（CK－MB）、钠（Na＋）、凝血酶原时间（PT）和活化部分凝血活酶时间（APTT）等数值的变化与HP治疗密切相关（P＜0．05）。本组治愈率为93．8％。结论：尽早采用床旁HP治疗可提高急性重度中毒抢救的成功率。“,”Objective:To investigate the efficacy of hemoperfusion (HP) therapy on the patients with acute server poisoning. Methods:65 patients with acute server poisoning treated in HP within 1.5 hours of hospitalization from Jan 2007 to Jun 2015 were. Several blood analyses including the analysis of blood gases and the blood concentration of ALT, AST, AL, Cr, CK-MB, PLT, Hb, PT, APTT and Acute Physiology And Chronic Health Evaluation Ⅱ (APACHE Ⅱ) were compared before and after 24-hour treatment. Results: After HP, the value of pH、PLT、HB and K+ was getting better (P<0.05), and APACHE Ⅱ score was decreased significantly (P<0.05). Meanwhile, the alteration of PaCO2、ALT、AST、ALB、Cr、CK-MB、Na+、PT and APTT was correlated with the effect of HP (P<0.05). Importantly, the mortality was 93.84%. Conclusions:The utilization of HP therapy at the early stage accompany with continues observation of APACHE Ⅱ score can improve recovery rate and reduce mortality of patients with acute severe poisoning.