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目的探讨Clusterin在肾脏远曲小管的表达与肾结石的关系。方法用免疫组化方法检测肾结石患者及对照组肾脏组织切片中clusterin表达情况,并作比较分析。结果 Clusterin在肾结石组及对照组肾远曲小管均有阳性表达,45例肾结石组患者平均表达强度评分为190.73±80.00,38例对照组为97.76±63.57,肾结石组表达强度评分明显高于对照组(P<0.001)。结论clusterin表达于肾远曲小管,在肾结石患者中表达明显增强,提示肾远曲小管损伤与肾结石的形成有关。
Objective To investigate the relationship between Clusterin expression in the distal tubule of the kidney and kidney stones. Methods Immunohistochemistry was used to detect the expression of clusterin in renal tissue sections of patients with kidney stones and control group, and comparative analysis was made. Results The expression of Clusterin was significantly higher in nephrolithiasis group and control group than in nephrolithiasis group. The average expression intensity of Clusterin in 45 cases of nephrolithiasis group was 190.73 ± 80.00, and in 97 cases of control group was 97.76 ± 63.57, In the control group (P <0.001). Conclusion The expression of clusterin in renal distal convoluted tubules is significantly increased in patients with renal stones, suggesting that renal distal tubule injury is associated with the formation of kidney stones.