应用放射免疫法测定８８例各种肝病患者血清透明质酸（ＨＡ）、Ⅲ型前胶原（ＰＣⅢ）和层粘连蛋白（ＬＮ）水平。结果发现随着肝病慢性化的进展，三者均逐渐增高，肝硬化时达最高值。在３３例经病理学证实的病例中，慢性活动性肝炎及肝硬化时ＨＡ、ＰＣⅢ、ＬＮ与肝纤维组织增生程度密切相关（Ｐ＜０．０５），且与白蛋白／球蛋白比值呈显著负相关（Ｐ＜０．０１）。提示ＨＡ、ＰＣⅢ、ＬＮ对肝纤维化诊断有较高价值。 Serum hyaluronic acid (HA), type Ⅲ procollagen (PCⅢ) and laminin (LN) levels were measured by radioimmunoassay in 88 patients with various liver diseases. The results showed that with the progress of chronic liver disease, the three were gradually increased, reached the highest value of cirrhosis. Among the 33 pathologically confirmed cases, HA, PCⅢ, LN in chronic active hepatitis and cirrhosis were closely related to the degree of hepatic fibrosis (P <0.05), and the ratio of albumin to globulin was significantly Negative correlation (P <0.01). Tip HA, PC Ⅲ, LN has a higher value in the diagnosis of liver fibrosis.