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树突状细胞(dendritic cell,DC)是目前为止发现的功能最强的专职抗原提呈细胞(antigenpresenting cell,APC),具有诱导机体产生初次免疫应答的独特功能。90年代开始,DC在肿瘤免疫治疗中的作用逐渐受到重视。本文就近年来的研究进展作一综述。 1 DC的起源、分布及特点 1.1 目前认为树突状细胞是一类具有典型树突状形态,膜表面高表达MHCⅡ类分子,能移行至淋巴器官和刺激初始型T细胞增殖活化,并具有一些相对特异性表面标志的细胞。1974年Steinman等提出DC起源于骨髓,与单核/巨噬细胞有共同的祖代。现在认为DC具有不同的起源,包括髓系、单核
Dendritic cells (DCs) are the most powerful professional antigen presenting cells (APCs) found so far and have the unique function of inducing a primary immune response. Since the 1990s, the role of DCs in tumor immunotherapy has gained increasing attention. This article reviews recent research progress. 1 The origin, distribution and characteristics of DC 1.1 Currently, dendritic cells are considered to have a typical dendritic morphology, high expression of MHC class II molecules on the membrane surface, the ability to migrate to lymphoid organs and to stimulate the proliferation and activation of primary T cells, and have some Relatively specific surface marker cells. In 1974, Steinman et al. proposed that DC originated from the bone marrow and had a common ancestor with monocytes/macrophages. DCs now have different origins, including myeloid and mononuclear