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目的探讨SOX13抗体(SOX13Ab)对急性起病自身免疫糖尿病的诊断价值。方法162例急性起病糖尿病患者根据谷氨酸脱羧酶抗体(GADAb)和蛋白酪氨酸磷酸酶抗体(IA2Ab)阳性与否分为经典[GADAb和(或)IA2Ab阳性]和非经典1型糖尿病(DM)(GADAb和IA2Ab均阴性)两亚组,正常对照组120名,分析SOX13Ab分布规律、该抗体阳性患者临床特征及其对胰岛功能的影响。结果(1)急性起病组和经典1型DM亚组SOX13Ab阳性率均高于正常对照组(9.3%vs2.5%,9.9%vs2.5%;均P<0.05);SOX13Ab(+)/GADAb(+)双阳性者6例(3.7%),无1例SOX13Ab(+)/IA2Ab(+)双阳性者;(2)SOX13Ab分布峰值处于发病年龄61～70岁;(3)SOX13Ab单一阳性组临床特征(包括代谢综合征相关指标异常程度等)与GADAb、IA2Ab单一阳性和抗体阴性组间差异无统计学意义(P>0.05);(4)SOX13Ab单一阳性组C肽介于GADAb、IA2Ab单一阳性和抗体阴性组之间。结论SOX13Ab检测可提高诊断急性起病自身免疫糖尿病的敏感性。
Objective To investigate the diagnostic value of SOX13 antibody (SOX13Ab) in the diagnosis of acute autoimmune diabetes. Methods 162 patients with acute onset diabetes were divided into classical [GADAb and (or) IA2Ab positive] and nonclassical type 1 diabetes mellitus (GADAb) and protein tyrosine phosphatase antibody (IA2Ab) (DM) (negative for both GADAb and IA2Ab) subgroups and 120 normal controls. The distribution of SOX13Ab, the clinical features of the antibody-positive patients and its effect on the islet function were analyzed. Results (1) The positive rates of SOX13Ab in acute onset group and classical type 1 DM subgroup were higher than those in normal control group (9.3% vs 2.5%, 9.9% vs 2.5%, all P <0.05) (2) SOX13Ab peak in the age of onset of 61 to 70 years; (3) single positive SOX13Ab (+) / IA2Ab (+) double positive; There was no significant difference in the clinical features (including the degree of abnormality related to metabolic syndrome, etc.) and GADAb, IA2Ab single antibody and antibody negative group (P> 0.05); (4) The single peptide of SOX13Ab was between GADAb and IA2Ab Between a single positive and an antibody negative group. Conclusion SOX13Ab test may improve the sensitivity of diagnosing acute onset autoimmune diabetes.