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目的 分析未分化型鼻咽癌的治疗效果及预后因素。方法 对 1990～ 2 0 0 0年收治的149例病理类型为未分化型的鼻咽癌患者的临床资料进行了回顾性分析 ,按 1992年福州鼻咽癌学术会议制定的分期标准分期 ,Ⅰ期 4例 ,Ⅱ期 33例 ,Ⅲ期 73例 ,Ⅳ 39例。治疗方案 :单纯放疗 78例 ,诱导化学药物治疗 (化疗 )加放疗 32例 ,同步化疗加放疗 39例。结果 未分化型鼻咽癌占鼻咽癌总数的 3 5 8%。 149例患者的 5年总生存率为 6 4 48% ,无瘤生存率为 6 0 35 % ,无远处转移生存率为77 0 5 % ,无局部区域复发生存率为 80 13%。影响预后的主要因素为N分期及TNM分期。结论 未分化型鼻咽癌是鼻咽癌中的一种少见型 ,N分期及TNM分期为影响预后的主要因素 ,以放疗为主的治疗方案 ,对未分型鼻咽癌有较好的疗效。
Objective To analyze the therapeutic effect and prognostic factors of undifferentiated nasopharyngeal carcinoma. Methods The clinical data of 149 patients with undifferentiated NPC from 1990 to 2000 were retrospectively analyzed. According to the staging staging system established by 1992 Fuzhou NPC Conference, stage Ⅰ 4 cases, 33 cases of stage Ⅱ, 73 cases of stage Ⅲ, 39 cases of Ⅳ. Treatment options: 78 cases of radiotherapy alone, induction chemotherapy (chemotherapy) plus radiotherapy in 32 cases, simultaneous chemotherapy plus radiotherapy in 39 cases. Results Undifferentiated nasopharyngeal carcinoma accounted for 35.8% of the total number of NPC. 149 patients had a 5-year overall survival rate of 64.48%, a disease-free survival rate of 6 035%, a distant metastasis-free survival rate of 77 0 5% and no local regional recurrence rate of 80 13%. The main factors affecting the prognosis of the N staging and TNM staging. Conclusions Undifferentiated nasopharyngeal carcinoma is a rare type in nasopharyngeal carcinoma, and N stage and TNM stage are the main factors affecting prognosis. Radiation-based treatment regimen has better curative effect on undifferentiated NPC .