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目的:确证依巴斯汀的结构。方法:通过对依巴斯汀的红外(IR)、质谱(MS)、氢-氢相关谱(H~1-H~1COSY)、碳谱(~(13)C- NMR、DEPT-90、DEPT-135)、碳-氢相关谱(HMQC)的解析,对所有的~1HNMR、~(13)CNMR谱的信号进行归属;讨论质谱的主要碎片离子可能的裂解方式和红外光谱特征吸收峰所对应的官能团的振动形式。结果:确证了依巴斯汀的结构。结论:通过对波谱学数据进行分析,确证了依巴斯汀是氧哌啶类结构。
Objective: To confirm the structure of ebastine. Methods: The bioavailability of ebastine was determined by IR, MS, H-1-H ~ 1COSY, ~ 13 C-NMR, DEPT-90, -135) and the analysis of the carbon-hydrogen correlation spectrum (HMQC), all the signals of ~ 1HNMR and ~ (13) CNMR spectra were assigned. The possible cleavage patterns of the major fragment ions and the corresponding characteristic peaks of IR spectra were discussed Of the vibrational form of the functional group. Results: The structure of ebastine was confirmed. Conclusion: Based on the spectroscopic data, it is confirmed that ebastine is an oxypiperidine structure.