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了解抗磷脂抗体 (APL)在慢性肺疾病和缺血性脑血管病中的因果关系 ,寻找预防脑动脉硬化的方法。脑梗塞组与肺心病组各 30例 ,抽血清以酶联免疫吸附法 (ELISA)原理 ,结合指数方式定量测定血清APL IgA、IgG、IgM水平 ,同时测定患者的血压、胆固醇 (T CHO)、甘油三脂 (TG)、载脂蛋白A(APOA)等进行对比。脑梗塞组APL IgA、IgG、IgM三项指标明显高于肺心病组 ,统计学差异显著 (P<0 0 0 1 ) ,T CHO、TG、APOA及收缩压 ,脑梗塞组同样高于肺心病组。慢性肺疾病患者的动脉硬化程度低 ,可能与体质下降、内源性肝素产生及免疫功能有关 ,对进行动脉硬化的预防研究有益
To understand the causal relationship between antiphospholipid antibody (APL) in chronic lung disease and ischemic cerebrovascular disease and to find ways to prevent cerebral arteriosclerosis. Serum levels of APL, IgA, IgG and IgM were determined by enzyme-linked immunosorbent assay (ELISA) and serum levels of excretion of IL-6, , Triglyceride (TG), apolipoprotein A (APOA), etc. were compared. The levels of APL, IgA, IgG and IgM in cerebral infarction group were significantly higher than those in pulmonary heart disease group (P <0.01). The levels of T CHO, TG, APOA, systolic blood pressure and cerebral infarction were also higher than those of pulmonary heart disease group. Low levels of atherosclerosis in patients with chronic lung disease may be related to physical decline, endogenous heparin production, and immune function, which may be beneficial in the prevention of atherosclerosis