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目的探讨托吡酯联合丙戊酸钠治疗难治性癫痫的临床疗效。方法 42例难治性癫痫患者,随机分为观察组和对照组,各21例。对照组患者单纯采用托吡酯治疗,观察组患者采用托吡酯联合丙戊酸钠治疗,观察两组临床效果。结果观察组患者各个疗程癫痫发作次数少于对照组(P<0.05);生活质量评分及临床治疗总有效率高于对照组(P<0.05)。结论托吡酯联合丙戊酸钠治疗难治性癫痫疗效显著,能有效的提高患者的生活质量,具有临床推广的价值。
Objective To investigate the clinical efficacy of topiramate plus valproate in the treatment of refractory epilepsy. Methods Forty-two patients with refractory epilepsy were randomly divided into observation group and control group, with 21 cases in each group. Patients in the control group were treated with topiramate only. Patients in the observation group were treated with topiramate combined with sodium valproate, and the clinical effects were observed. Results The number of epileptic seizures in each observation group was less than that of the control group (P <0.05). The quality of life score and the total effective rate of clinical treatment were higher than those in the control group (P <0.05). Conclusion Topiramate combined with sodium valproate treatment of refractory epilepsy significant effect, can effectively improve the quality of life of patients with clinical value.