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挤压综合征时的急性肾衰已为人们所熟知,从损伤肌肉中释出的肌红蛋白等细胞内容物可损害肾脏,造成少尿和肾功能减退。近几年认识到,除外伤外还有许多其他原因可引起横纹肌溶解和肌红蛋白尿,称之为非创伤性横纹肌溶解症(NTR)。本症十分常见,已成为导致急性肾衰的重要原因之一,临床表现也颇具特征,值得引起重视。NTR的病因任何能影响肌细胞能量转运、贮存或利用的因素均可导致横纹肌损伤和坏死。常见病因有:(1)能量消耗增加(过度运动、惊厥、高热);(2)能量生成减少(缺钾、乙醇、磷酸酶缺乏、非酮症性高渗性昏迷);(3)氧合障碍
Acute renal failure during crush syndrome has been well known, and cellular contents such as myoglobin released from injured muscles can damage the kidneys, causing oliguria and diminished renal function. In recent years, it has been recognized that there are many other causes of rhabdomyolysis and myoglobinuria besides trauma, which are called non-traumatic rhabdomyolysis (NTR). This disease is very common, has become one of the important causes of acute renal failure, clinical features are quite characteristic, it deserves attention. Etiology of NTR Any factor that affects the transport, storage or utilization of energy in muscle cells can lead to striated injury and necrosis. Common causes are: (1) increased energy expenditure (excessive exercise, convulsions, hyperthermia); (2) decreased energy production (potassium deficiency, alcohol, phosphatase deficiency and nonketotic hypertonic coma); (3) obstacle