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本实验表明,恒河猴血、尿中甲醇代谢产物甲醛和甲酸浓度相差很大,血和尿中甲酸分别是甲醛的30和29倍。体液中甲酸浓度,以房水最高,血次之,尿最低。甲酸动态变化为一次给毒后升至最高时间,房水为24h,血、尿为12h,降至给毒前水平均为72h。典型中毒表现为代谢性酸中毒和眼底改变,最终死亡。代谢性酸中毒和中毒死亡与血中甲酸浓度密切相关,眼底改变则与房水甲酸浓度变化基本一致。提示恒河猴甲醇中毒模型与人相似。
This experiment shows that blood, urine methanol metabolites formaldehyde and formic acid concentrations vary widely, blood and urine formic acid, respectively, 30 and 29 times that of formaldehyde. Body acid concentration of formic acid to the highest aqueous humor, blood, urinary lowest. Formic acid dynamic change to a maximum time after poisoning, aqueous humor for 24h, blood, urine for 12h, reduced to pre-toxic levels were 72h. Typical poisoning manifested as metabolic acidosis and fundus changes, the final death. Metabolic acidosis and poisoning death and the concentration of formic acid in the blood is closely related to changes in the fundus and aqueous formaldehyde concentration is basically the same. Tip rhesus monkey methanol poisoning model and similar.