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厦门大学生命科学学院吴乔课题组和林天伟课题组合作发现了通过诱导细胞自噬性死亡,从而有效抑制黑色素瘤细胞生长的信号通路,这将为治疗黑色素瘤开启新思路并提供新靶点和独特的先导化合物。2013年12月9日,该成果于Nature Chemical Biology在线发表。吴乔课题组研究发现,当把THPN这一小分子化合物与黑色素瘤细胞孵育后,核受体TR3被可以自主
Xiamen University College of Life Sciences Wu Qiao and Lin Tianwei task force team found that by inducing autophagic cell death, thereby effectively inhibiting melanoma cell growth signal pathway, which will open up new ideas for the treatment of melanoma and provide new targets and Unique lead compound. This result was published online at Nature Chemical Biology on December 9, 2013. Wu Qiao research group found that when THPN this small molecule compound and melanoma cells after incubation, the nuclear receptor TR3 can be autonomic