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目的:探讨小剂量左甲状腺素治疗良性甲状腺结节的临床疗效。方法:选择2014年5月至2015年5月期间笔者所在医院收治的150例良性甲状腺结节患者作为研究对象,随机分为观察组和对照组,观察组给予小剂量左甲状腺素治疗,对照组患者给予安慰剂治疗,比较两组患者的生化指标和甲状腺体积变化。结果:治疗前,两组患者的促甲状腺激素和游离甲状腺素的水平比较,均无统计学意义(P>0.05);治疗后,观察组患者的促甲状腺激素显著低于对照组,游离甲状腺素水平显著高于对照组,组间差异具有统计学意义(P<0.05);治疗前,两组患者的甲状腺结节大小比较无显著差异(P>0.05);治疗后,观察组患者的甲状腺结节体积显著小于对照组,组间比较有统计学意义(P<0.05)。结论:小剂量左甲状腺素治疗良性甲状腺结节的临床效果显著,可有效抑制结节生长,改善患者的各项生化指标,值得在临床上推广。
Objective: To investigate the clinical efficacy of low-dose levothyroxine in the treatment of benign thyroid nodules. Methods: A total of 150 patients with benign thyroid nodules who were admitted to our hospital from May 2014 to May 2015 were selected as study subjects and randomly divided into observation group and control group. The observation group was treated with low-dose levothyroxine and the control group Patients were given placebo and the biochemical and thyroid volume changes were compared between the two groups. Results: Before treatment, the levels of thyroid stimulating hormone and free thyroxine in both groups were not statistically significant (P> 0.05). After treatment, the levels of thyrotropin in the observation group were significantly lower than those in the control group. Free thyroxine (P <0.05). Before treatment, there was no significant difference in thyroid nodule size between the two groups (P> 0.05). After treatment, the thyroid gland of the observation group was significantly higher than that of the control group The size of the section was significantly smaller than that of the control group, with statistical significance (P <0.05). Conclusions: The clinical efficacy of low-dose levothyroxine in the treatment of benign thyroid nodules is significant, which can effectively inhibit the growth of nodules and improve the biochemical indexes of patients. It is worth to be popularized clinically.