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目的探讨晚期肺鳞癌血清鳞癌相关抗原(SCC-Ag)检测的临床价值。方法 80例肺癌患者为研究对象,其中鳞癌50例,腺癌14例,小细胞肺癌(SCLC)11例,大细胞肺癌(LCLC)5例,另选45例良性病变患者,对所有患者进行SCC-Ag检测。结果肺鳞癌阳性率为68.00%,肺腺癌阳性率14.29%,SCLC阳性率18.18%,LCLC阳性率20.00%,对照组2.22%。经手术前后动态观察显示,根治术后SCC-Ag可在3 d内转阴,与其他术式比较差异有统计学意义(P<0.05)。结论 SCC-Ag为肺鳞癌特殊标记物,是对患者手术效果与远期预后进行预测的重要参考指标。
Objective To investigate the clinical value of detecting serum squamous cell carcinoma-associated antigen (SCC-Ag) in advanced squamous cell carcinoma of the lung. Methods 80 cases of lung cancer patients were studied, including 50 cases of squamous cell carcinoma, 14 cases of adenocarcinoma, 11 cases of small cell lung cancer (SCLC), 5 cases of large cell lung cancer (LCLC), 45 cases of benign lesions, all patients SCC-Ag test. Results The positive rate of lung squamous cell carcinoma was 68.00%, the positive rate of lung adenocarcinoma was 14.29%, the positive rate of SCLC was 18.18%, the positive rate of LCLC was 20.00%, and that of the control group was 2.22%. Dynamic observation before and after surgery showed that SCC-Ag could be negative within 3 days after radical operation, with significant difference compared with other surgical procedures (P <0.05). Conclusion SCC-Ag is a special marker of squamous cell carcinoma of lung, which is an important reference index for predicting the surgical outcome and long-term prognosis of patients.