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目的:探讨嗜酸粒细胞和嗜酸粒细胞阳离子蛋白(ECP)在气道高反应性患者诊断中的价值。方法:378名慢性咳嗽和/或胸闷病人作激发试验,激发试验阳性者作进一步的检查,包括血清嗜酸粒细胞、痰液嗜酸粒细胞和ECP。排除其它疾病后,这些病人被拟诊为支气管哮喘,根据GINA方案进行规范治疗,并追踪24个月。结果:83名患者诊断为哮喘,25名诊断为非哮喘,哮喘患者血清嗜酸细胞计数为(4.8±3.5)%,明显高于非哮喘患者[(1.2±2.1)%,P<0.01]。哮喘患者痰液中的嗜酸细胞计数、ECP分别为[(9.4±3.2)和(289.4±112.3)μg/L],明显高于非哮喘患者[(2.1±1.3)%和(57.7±18.7)μg/L,P<0.01]。痰液中的嗜酸细胞计数和ECP诊断哮喘的结果和追踪结果一致性较高,而血清嗜酸细胞计数为中度一致性。结论:痰液中的嗜酸细胞、ECP对哮喘的诊断和鉴别诊断有重要的帮助。
Objective: To investigate the value of eosinophils and eosinophil cationic protein (ECP) in the diagnosis of patients with airway hyperresponsiveness. METHODS: A total of 378 patients with chronic cough and / or chest tightness were challenged and challenged with positive tests for further examination, including serum eosinophils, sputum eosinophils and ECP. After excluding other diseases, these patients were diagnosed with bronchial asthma and were treated according to the GINA protocol and followed up for 24 months. Results: 83 patients were diagnosed as asthma and 25 were diagnosed as non-asthmatic. The serum eosinophil count in asthmatic patients was (4.8 ± 3.5)%, significantly higher than that in non-asthmatic patients ([1.2 ± 2.1]%, P <0.01]. The eosinophil counts and ECP in the sputum of asthmatic patients were significantly higher than those in non-asthmatic patients [(2.1 ± 1.3)% vs (57.7 ± 18.7), (9.4 ± 3.2) and (289.4 ± 112.3) μg / μg / L, P <0.01]. Sputum eosinophil count and ECP diagnosis of asthma and follow-up results of the higher agreement, and serum eosinophil count was moderately consistent. Conclusion: Eosinophilic sputum, ECP of asthma diagnosis and differential diagnosis of important help.