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目的:探讨血浆置换术对孕妇血清中IgG抗体及血液内环境的影响。方法:对109例抗人球蛋白法测定抗体效价高于1:64的孕妇,在血浆置换术前后,进行IgG抗体的表达水平及血液中RBC、Hb和HCT量的变化检测。结果:所有孕妇在血浆置换术后IgG含量均有不同程度的降低,而RBC、Hb和HCT量均有不同程度的提高。血浆置换术后1年,除1例在早产后死亡外,其他108例未发生新生儿溶血病。结论:采用血浆置换以及补足新鲜血浆的手段,可明显降低IgG抗体表达,并能防止置换后贫血症的发生。
Objective: To investigate the effect of plasma exchange on serum IgG and blood in pregnant women. Methods: 109 pregnant women with antibody titers higher than 1: 64 were detected by anti-human globulin method. The levels of IgG antibody and the amount of RBC, Hb and HCT in blood were detected before and after plasmapheresis. Results: All pregnant women had different levels of IgG after plasmapheresis, while the amounts of RBC, Hb and HCT increased to some extent. One year after plasmapheresis, except one case died after premature delivery, the other 108 cases did not have hemolytic disease of newborn. Conclusion: The use of plasma exchange and make up of fresh plasma can significantly reduce the expression of IgG antibody, and prevent the occurrence of anemia after replacement.