自从1963年Goldberg等在多种哺乳动物、鸟类睾丸组织和精子中发现精子特异性乳酸脱氢酶C4(LDH-C4)以来,国内外对其分布的特异性及其与性成熟、生育过程的密切关系作了深入研究。近20年来,LDH-C4一直作为避孕疫苗的重要候选对象之一,受到国内外学者的关注。现就将近年来有关LDH-C4研究进展简要综述如下。1 LDH-C4表达的遗传控制LDH-C4的合成受LDH C基因的控制,该基因定位 Since the discovery of sperm-specific lactate dehydrogenase C4 (LDH-C4) in many mammalian, bird testicular tissues and sperm by Goldberg in 1963, the specificity of its distribution at home and abroad and its relationship with sexual maturation, fertility In-depth study of the close relationship. For nearly 20 years, LDH-C4 has been one of the important candidates for contraception vaccine, which has attracted the attention of domestic and foreign scholars. Now in recent years on LDH-C4 research progress is briefly summarized as follows. 1 Genetic Control of LDH-C4 Expression The synthesis of LDH-C4 is controlled by the LDH C gene, which is localized