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目的探讨胃腺癌患者术前四项凝血功能指标检测值与临床病理学方面的相关性。方法回顾性分析84例胃腺癌患者术前凝血酶原时间(PT)、部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、凝血酶时间(TT)值。结果 APTT在不同年龄组间有统计学差异,低年龄段胃腺癌APTT较高年龄者延长,而TT较后者缩短(P<0.05)。TT在III期胃腺癌较I~II期缩短(P<0.05)。FIB在高年龄组、高分期、肿瘤范围≥5cm、淋巴结转移数>2枚者要高于低年龄组、低分期、肿瘤范围<5cm、淋巴结转移数0~2枚者(P<0.05)。其余凝血指标在年龄、性别、组织学分级、肿瘤大小、淋巴结阴阳性方面差异无统计学意义(P>0.05)。结论不同年龄组胃癌患者APTT、TT、FIB不同,提示在研究胃癌凝血功能时要对不同年龄组进行分析。胃癌患者凝血功能紊乱,特别是恶性程度高的胃腺癌患者FIB升高,提示FIB可作为监测胃癌恶性程度的指标。
Objective To investigate the correlation between the preoperative values of four coagulation indexes and clinicopathological features in patients with gastric adenocarcinoma. Methods The preoperative prothrombin time (PT), partial thromboplastin time (APTT), fibrinogen (FIB) and thrombin time (TT) were analyzed retrospectively in 84 patients with gastric adenocarcinoma. Results There was a significant difference in APTT among different age groups. APTT of gastric adenocarcinoma in younger age group was higher than that of higher age group, while TT was shorter than that of the latter group (P <0.05). TT was shorter in stage III gastric adenocarcinoma than in stage I ~ II (P <0.05). FIB in high age group, high staging, tumor range≥5cm, lymph node metastasis number> 2were higher than low age group, low staging, tumor size <5cm, number of lymph node metastasis 0-2 (P <0.05). The remaining coagulation index in age, gender, histological grade, tumor size, lymph node positive and negative aspects no significant difference (P> 0.05). Conclusion The APTT, TT and FIB in different age groups are different, suggesting that different age groups should be analyzed when studying the coagulation function of gastric cancer. Patients with gastric cancer coagulation disorders, especially in patients with high degree of malignancy of gastric adenocarcinoma increased FIB, suggesting that FIB can be used as indicators of monitoring the degree of malignancy of gastric cancer.