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目的为了探讨神经肽与缺血性脑血管病的发病关系。方法应用放射免疫分析法检测脑血管病患者血浆中ＣＧＲＰ、ＡＮＰ的含量表达。结果急性期脑梗塞患者血浆ＣＧＲＰ含量低于恢复期及正常对照组，重型低于轻型及中型，差异显著（Ｐ＜０．０１）；急性期脑梗塞患者血浆ＡＮＰ含量高于恢复期及正常对照组（Ｐ＜０．０１），重型高于轻型（Ｐ＜０．０１）及中型（Ｐ＜０．０５）；正常对照组血浆ＣＧＲＰ、ＡＮＰ含量呈正直线相关关系，急性期脑梗塞患者血浆ＣＧＲＰ、ＡＮＰ含量无直线相关关系。结论神经肽参与脑血管病的发病过程，神经肽检测可以作为脑血管病的临床分型、判断预后的客观指标
Objective To investigate the relationship between neuropeptide and ischemic cerebrovascular disease. Methods Radioimmunoassay was used to detect the plasma levels of CGRP and ANP in patients with cerebrovascular disease. Results The plasma levels of CGRP in patients with acute cerebral infarction were significantly lower than those in the recovery and control groups (P <0.01). The levels of plasma ANP in patients with acute cerebral infarction were significantly higher than those in the recovery and normal controls (P <0.01). The levels of CGRP and ANP in the normal control group were positively correlated with the levels of plasma CGRP , ANP content no linear correlation. Conclusions Neuropeptide is involved in the pathogenesis of cerebrovascular disease. Neuropeptide detection can be used as a clinical classification of cerebrovascular disease and an objective indicator of prognosis