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目的观察老年女性冠心病抑郁患者血浆脑钠素(pro-BNP)及超敏C-反应蛋白(Hs-CRP)水平的变化。方法把90例CHD抑郁患者分为急性心肌梗死(AMI)组、不稳定型心绞痛(UAP)组和稳定型心绞痛(SAP)组各30例;另外,按照Gensini积分的三分位间距将研究对象分为A组(Gensini积分<26分)、B组(Gensini积分26～54分)和C组(Gensini积分>54分),检测不同类型CHD患者血浆pro-BNP和Hs-CRP的浓度变化。结果 CHD抑郁患者血浆pro-BNP、Hs-CRP水平及其比值明显高于对照组(p<0.05);急性心肌梗死患者血浆pro-BNP、Hs-CRP显著高于不稳定型心绞痛及稳定型心绞痛病人,不稳定型心绞痛患者高于稳定型心绞痛患者(p<0.05);C组血浆pro-BNP、Hs-CRP水平明显高于B组及A组,B组显著高于A组(p<0.05)。结论女性CHD抑郁患者pro-BNP、Hs-CRP水平明显升高,且在一定程度上反映了病情、病变的严重程度,可作为CHD危险分层及病变程度评估的参考指标。
Objective To observe the changes of plasma brain natriuretic peptide (pro-BNP) and high-sensitivity C-reactive protein (Hs-CRP) in elderly patients with coronary heart disease and depression. Methods Ninety patients with depression of CHD were divided into AMI group, 30 cases of unstable angina pectoris (UAP) group and 30 cases of stable angina pectoris group (SAP). In addition, according to the interquartile range of Gensini score, The patients were divided into group A (Gensini score <26), group B (Gensini score 26-54) and group C (Gensini score> 54) to detect the changes of plasma pro-BNP and Hs-CRP concentrations in different types of CHD patients. Results The levels of pro-BNP, Hs-CRP and the ratio of Hs-CRP in patients with CHD were significantly higher than those in control group (p <0.05). The levels of pro-BNP and Hs-CRP in patients with acute myocardial infarction were significantly higher than those in patients with unstable angina and stable angina The levels of pro-BNP and Hs-CRP in group C were significantly higher than those in group B and group A (P <0.05), and were significantly higher in group B than those in group A (p <0.05) ). Conclusion The levels of pro-BNP and Hs-CRP in women with CHD depression were significantly increased, and to some extent reflect the severity of the disease, the severity of the disease, CHD risk stratification and disease can be used as a reference level assessment.