运用超声波作用原理，改变菌丝体胞壁对庆大霉素（ｇｅｎｔａｍｉｃｉｎ，ＧＭ）的吸附性能，使部分被胞壁吸附的ＧＭ释放到发酵液中，从而解除胞内产物抑制，促进产物合成。研究表明，超声波在线处理ＧＭ发酵液的最佳剂量为９５μＡ×０．０８ｓ×５／ｍｌ发酵液，最佳处理间隔４０～５０ｍｉｎ，运用超声波处理８０～９０ｈ龄的发酵液可明显提高ＧＭ发酵效价１．５倍 By using the principle of ultrasonic wave, the adsorption capacity of gentamicin (GM) on the cell wall of mycelium was changed, and part of GMs adsorbed by the cell wall were released into the fermentation broth, thereby inhibiting the intracellular product inhibition and promoting the product synthesis. The results showed that the optimum dosage of ultrasonic treatment of GM fermentation broth was 95μA × 0.08s × 5 / ml fermentation broth with the best treatment interval of 40 ~ 50min. Ultrasound treatment of 80 ~ 90h fermentation broth significantly improved GM fermentation efficiency Price 1.5 times