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胃癌肿瘤相关抗原(MG-Ag)是最近发现的一种新的肿瘤标志物,MG-Ag对胃癌的早期诊断已有报道,而MG-Ag在其他肿瘤中的含量变化报道较少,为此我们对161例不同的肿瘤患者和51例正常人血清进行了MG-Ag和癌胚抗原(CEA)的含量测定。现将结果报道如下。 材料和方法 一、对象: (一正常对照组51例(男32,女19),年龄30～65岁,均为健康查体人员,无心、肝、肾及其他疾病。 (二)观察组161例(男95,女66),年龄32～71岁。其中胃癌30例,食道癌27例,肺癌28例,结肠癌21例,直肠癌16例,乳腺癌15例,肝癌24例。均为我院门诊及住院病人,经病理、实验室及各种检查证实为肿瘤患者。 二、方法:受检者均早晨取空腹静脉血2～3ml,分离血清,-30℃冰冻保存待测。MG-Ag试剂盒由第四军医大学西京医院全军消化中心提供。CEA试剂盒由上海放射免疫分析技术研究所供给。均按说明书操作。仪器为国营西安二六二厂生产的FJ-2008P全自动γ放射免疫计数器测定,数据由微机自动处理。 结果 一、正常人血清MG-Ag含量为5.08±2.14u/ml,CEA的含量为7.81±2.42μg/L,观察组血清MG-Ag、CEA的含量与正常人比较,经方差分析均有显著差异,其结果见表1。
Gastric cancer-associated antigen (MG-Ag) is a newly discovered tumor marker. MG-Ag has been reported for the early diagnosis of gastric cancer, and MG-Ag is rarely reported in other tumors. We measured MG-Ag and carcinoembryonic antigen (CEA) levels in 161 patients with different tumors and 51 normal controls. The results are reported below. Materials and Methods I. Objects: (A normal control group of 51 patients (male 32, female 19), aged 30 to 65 years old, are all physical examination personnel, no heart, liver, kidney and other diseases. Cases (male 95, female 66), aged 32-71 years old, including 30 cases of gastric cancer, 27 cases of esophageal cancer, 28 cases of lung cancer, 21 cases of colon cancer, 16 cases of rectal cancer, 15 cases of breast cancer, and 24 cases of liver cancer. Outpatients and inpatients in our hospital were confirmed as tumor patients by pathology, laboratories, and various examinations.2.Methods: Subjects took 2-3 ml of empty venous blood in the morning, separated serum, and kept frozen at -30°C for testing.MG The Ag kit is provided by the Military Digestive Center of the Xijing Hospital of the Fourth Military Medical University, and the CEA kit is supplied by the Shanghai Institute of Radioimmunoassay.All of them are operated according to the instructions.The instrument is manufactured by the State-owned Xi’an 262 Factory FJ-2008P. The gamma radioimmunoassay counter was used to measure the data and the data was automatically processed by a computer.Results 1. Normal human serum MG-Ag content was 5.08±2.14u/ml, CEA content was 7.81±2.42μg/L, serum MG-Ag and CEA were observed in the observation group. Compared with normal people, the variance analysis showed significant differences. The results are shown in Table 1.