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目的探讨治疗高危型HPV感染的宫颈病变安全、有效的方法。方法选取2016年1月-2017年1月在黄石市妇幼保健院妇女保健科进行妇女病普查,并确诊为高危型HPV感染的宫颈病变(单纯高危型HPV感染和/或CINⅠ)患者180例,随机分为宫颈聚焦超声治疗组(A组)、宫颈LEEP刀治疗组(B组)和对照组(C组),比较3组患者HPV-DNA滴度、治愈率、术中出血量、手术时间和术后排液时间。结果治疗后6、12个月后A、B两组与C组比较,HPV转阴率高、HPV-DNA滴度降低时间短,差异有统计学意义(P<0.05);A、B两组治疗组总治愈率比较,差异无统计学意义(P>0.05)。A组术中出血量、手术时间及术后阴道流液时间均明显低于B组,差异有统计学意义(P<0.05)。结论高危型HPV感染的宫颈病变患者,宫颈聚焦超声术的治疗在术中出血量、手术时间及术后阴道流血时间等方面均优于宫颈LEEP刀术。
Objective To explore a safe and effective method for the treatment of cervical lesions in high-risk HPV infection. Methods From January 2016 to January 2017, 180 cases of cervical lesions (simple high-risk HPV infection and / or CINⅠ) were screened for women’s disease in Huangshi MCH and were diagnosed as high-risk HPV infection randomly The patients were divided into three groups: the cervical focus ultrasound group (group A), cervical LEEP knife group (group B) and the control group (group C). The HPV-DNA titer, cure rate, intraoperative blood loss, Postoperative drainage time. Results After 6 and 12 months of treatment, the negative rates of HPV negative conversion rate and HPV-DNA titer were shorter in groups A and B than in group C (P <0.05); in groups A and B The total cure rate in the treatment group, the difference was not statistically significant (P> 0.05). The intraoperative blood loss, operation time and postoperative vaginal fluid time in group A were significantly lower than those in group B, with significant difference (P <0.05). Conclusion High-risk HPV infection in patients with cervical lesions, cervical focus ultrasound in the treatment of intraoperative bleeding, operative time and postoperative vaginal bleeding time are superior to cervical LEEP surgery.