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目的探讨不同剂量和不同给药方式的阿托品对急性重症有机磷农药中毒(AOPP)的疗效和安全性。方法入选126例 AOPP 患者随机分为 A、B、C 3组,分别给予不同剂量和给药方式的阿托品。A 组首剂大剂量(5～10mg)静脉推注加静脉滴注法1～3 mg/min;B 组每次静脉推注10～25 mg;C 组每次静脉推注5～10 mg。B、C 两组均间隔5～10 min 给药1次,3组出现阿托品化后逐渐减量,直至停药。随访观察3组患者的阿托品中毒率、治愈率和死亡率。结果.A 组阿托品中毒率1.9%,治愈率98.1%,死亡率1.9%;B 组阿托品中毒率12.5%,治愈率93.7%,死亡率6.3%;C 组阿托品中毒率8.7%,治愈率95.7%,死亡率4.3%。结论持续静脉滴注阿托品抢救 AOPP 安全,疗效好,可避免阿托品中毒。
Objective To investigate the efficacy and safety of atropine with different dosages and administration methods in acute severe organophosphorus pesticide poisoning (AOPP). Methods A total of 126 patients with AOPP were randomly divided into A, B and C groups, and were given atropine at different dosage and mode of administration. A group of the first dose of large doses (5 ~ 10mg) intravenous injection plus intravenous infusion of 1 ~ 3 mg / min; B group intravenous injection of 10 ~ 25 mg; C group intravenous injection of 5 ~ 10 mg. Groups B and C were administered once every 5 to 10 minutes, and in the 3 groups, atropine was gradually reduced and stopped until withdrawal. Atropine poisoning rate, cure rate and mortality rate were observed in 3 groups. Results A group of atropine poisoning rate of 1.9%, the cure rate was 98.1%, the mortality rate of 1.9%; B group atropine poisoning rate of 12.5%, the cure rate of 93.7%, the mortality rate of 6.3%; C group atropine poisoning rate of 8.7% cure rate of 95.7% , The mortality rate of 4.3%. Conclusion continuous intravenous infusion of Atropine rescue AOPP safety, good effect, to avoid atropine poisoning.