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用聚合酶链反应—限制性片段长度多态性（ＰＣＲ－ＲＦＬＰ）方法分析了原发性肝癌（ＰＨＣ）组织中Ｐ５３基因第２４９密码子的点突变，突变率为４８．４％，结果表明Ｐ５３基因的突变可能与环境致癌物ＡＦＢ１和ＨＢＶ有关。
The point mutation of the 249 codon of P53 gene in primary liver cancer (PHC) tissues was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The mutation rate was 48.4%. Mutations in the P53 gene may be related to environmental carcinogens AFB1 and HBV.